Publications
Peer-reviewed research from the Mackenzie Lab.
A curated selection from Google Scholar, spanning two decades of work on dopamine circuits, VGLUT2 and the subthalamic nucleus. For the complete list including conference abstracts and protocols, visit the Scholar profile.
Showing 56 of 56 publications
- 2025Cited by 1
Spatio-molecular analysis of primate subthalamus defines anatomical domains relevant to Parkinson's disease and neuropsychiatry
S Dumas, C Francois, C Karachi, Å Wallén-Mackenzie
bioRxiv 2025.05.21.655268
- 2024Cited by 65
Architecture of the subthalamic nucleus
AA Prasad, Å Wallén-Mackenzie
Communications Biology 7 (1), 78
- 2024Cited by 17
Concerning neuromodulation as treatment of neurological and neuropsychiatric disorder: selective targeting of the subthalamic nucleus and para-subthalamic area
A Ricci, E Rubino, GP Serra, Å Wallén-Mackenzie
Neuropharmacology 256, 110003
- 2024Cited by 1
Opto-Avoidance-Elevated Plus Maze protocol to study positive or negative valence upon optogenetic stimulation in the mouse brain
GP Serra, F Georges, Å Wallén-Mackenzie
STAR Protocols 5 (4)
- 2023Cited by 21
A role for the subthalamic nucleus in aversive learning
GP Serra, A Guillaumin, B Vlcek, L Delgado-Zabalza, A Ricci, E Rubino, et al.
Cell Reports 42 (11)
- 2023Cited by 14
Anatomical characterisation of three different psychosurgical targets in the subthalamic area
MN Santin, N Tempier, H Belaid, M Zenoni, S Dumas, et al.
Brain Structure and Function 228 (8), 1977–1992
- 2023Cited by 6
Vesicular glutamate transporter 2 expression in the ventral tegmental area of outbred male rats following exposure to nicotine and alcohol
M Vrettou, SB Thalhammer, AL Svensson, S Dumas, KW Nilsson, et al.
Drug and Alcohol Dependence Reports 8, 100180
- 2023Cited by 3
Increased sucrose consumption in mice gene-targeted for Vmat2 selectively in NeuroD6-positive neurons of the ventral tegmental area
Z Bimpisidis, GP Serra, N König, Å Wallén-Mackenzie
Frontiers in Molecular Neuroscience 16, 1069834
- 2023Cited by 1
Aldh1a1 and additional markers of dopamine cell heterogeneity in substantia nigra and ventral tegmental area identified as preserved in two transgenic α-synuclein mouse models
B Vlcek, S Dumas, S Ekmark-Lewén, E Rubino, M Ingelsson, et al.
Exploration of Neuroprotective Therapy 3 (5), 299–327
- 2022Cited by 2
Improving well-being and survival in the 6-OHDA lesion model of Parkinson's disease in mice: literature review and step-by-step protocol
A Guillaumin, B Vlcek, Å Wallén-Mackenzie
Scandinavian Journal of Laboratory Animal Science 48, 1–21
- 2021Cited by 56
Experimental investigation into the role of the subthalamic nucleus (STN) in motor control using optogenetics in mice
A Guillaumin, GP Serra, F Georges, Å Wallén-Mackenzie
Brain Research 1755, 147226
- 2021Cited by 17
Midbrain dopamine neurons defined by TrpV1 modulate psychomotor behavior
GP Serra, A Guillaumin, S Dumas, B Vlcek, Å Wallén-Mackenzie
Frontiers in Neural Circuits 15, 726893
- 2021Cited by 9
DNA methylation of Vesicular Glutamate Transporters in the mesocorticolimbic brain following early-life stress and adult ethanol exposure
M Vrettou, L Yan, KW Nilsson, Å Wallén-Mackenzie, I Nylander, et al.
Scientific Reports 11 (1), 15322
- 2020Cited by 69
Spatio-molecular domains identified in the mouse subthalamic nucleus and neighboring glutamatergic and GABAergic brain structures
Å Wallén-Mackenzie, S Dumas, M Papathanou, MM Martis Thiele, B Vlcek, et al.
Communications Biology 3 (1), 338
- 2020Cited by 19
Two different real-time place preference paradigms using optogenetics within the ventral tegmental area of the mouse
Z Bimpisidis, N König, Å Wallén-Mackenzie
Journal of Visualized Experiments
- 2020Cited by 18
Selective Knockout of the Vesicular Monoamine Transporter 2 (Vmat2) Gene in Calbindin2/Calretinin-Positive Neurons
N König, Z Bimpisidis, S Dumas, Å Wallén-Mackenzie
Frontiers in Behavioral Neuroscience 14, 578443
- 2019Cited by 50
Developmental co-expression of Vglut2 and Nurr1 in a mes-di-encephalic continuum precedes dopamine and glutamate neuron specification
S Dumas, Å Wallén-Mackenzie
Frontiers in Cell and Developmental Biology 7, 307
- 2019Cited by 47
Off-target effects in transgenic mice: characterization of dopamine transporter (DAT)-Cre transgenic mouse lines exposes multiple non-dopaminergic neuronal clusters
M Papathanou, S Dumas, H Pettersson, L Olson, Å Wallén-Mackenzie
eNeuro 6 (5)
- 2019Cited by 34
The NeuroD6 subtype of VTA neurons contributes to psychostimulant sensitization and behavioral reinforcement
Z Bimpisidis, N König, S Stagkourakis, V Zell, B Vlcek, S Dumas, B Giros, et al.
eNeuro 6 (3)
- 2019Cited by 30
Neurocircuitry of reward and addiction: potential impact of dopamine–glutamate co-release as future target in substance use disorder
Z Bimpisidis, Å Wallén-Mackenzie
Journal of Clinical Medicine 8 (11), 1887
- 2019Cited by 14
VGLUT2 rs2290045 genotype moderates environmental sensitivity to alcohol-related problems in three samples of youths
M Vrettou, KW Nilsson, C Tuvblad, M Rehn, C Åslund, AK Andershed, et al.
European Child & Adolescent Psychiatry 28 (10), 1329–1340
- 2018Cited by 49
Targeting VGLUT2 in mature dopamine neurons decreases mesoaccumbal glutamatergic transmission and identifies a role for glutamate co-release in synaptic plasticity
M Papathanou, M Creed, MC Dorst, Z Bimpisidis, S Dumas, H Pettersson, et al.
Frontiers in Neural Circuits 12, 64
- 2018Cited by 13
Validated multi-step approach for in vivo recording and analysis of optogenetically evoked glutamate in the mouse globus pallidus
T Viereckel, Å Konradsson-Geuken, Å Wallén-Mackenzie
Journal of Neurochemistry 145 (2), 125–138
- 2017Cited by 53
Disrupting glutamate co-transmission does not affect acquisition of conditioned behavior reinforced by dopamine neuron activation
DV Wang, T Viereckel, V Zell, Å Konradsson-Geuken, CJ Broker, et al.
Cell Reports 18 (11), 2584–2591
- 2017Cited by 28
Ethanol affects limbic and striatal presynaptic glutamatergic and DNA methylation gene expression in outbred rats exposed to early-life stress
M Vrettou, L Granholm, A Todkar, KW Nilsson, Å Wallén-Mackenzie, et al.
Addiction Biology 22 (2), 369–380
- 2016Cited by 61
Midbrain gene screening identifies a new mesoaccumbal glutamatergic pathway and a marker for dopamine cells neuroprotected in Parkinson's disease
T Viereckel, S Dumas, CJA Smith-Anttila, B Vlcek, Z Bimpisidis, et al.
Scientific Reports 6 (1), 35203
- 2016Cited by 26
Reduced Vglut2/Slc17a6 gene expression levels throughout the mouse subthalamic nucleus cause cell loss and structural disorganization
N Schweizer, T Viereckel, CJA Smith-Anttila, K Nordenankar, E Arvidsson, et al.
eNeuro 3 (5), 0264-16.2016
- 2015Cited by 161
In situ proximity ligation assay (PLA)
S Bagchi, R Fredriksson, Å Wallén-Mackenzie
ELISA: Methods and Protocols, 149–159
- 2015Cited by 53
SLC10A4 is a vesicular amine-associated transporter modulating dopamine homeostasis
M Larhammar, K Patra, M Blunder, L Emilsson, C Peuckert, E Arvidsson, et al.
Biological Psychiatry 77 (6), 526–536
- 2015Cited by 52
Cre-driven optogenetics in the heterogeneous genetic panorama of the VTA
S Pupe, Å Wallén-Mackenzie
Trends in Neurosciences 38 (6), 375–386
- 2015Cited by 38
Increased hippocampal excitability and impaired spatial memory function in mice lacking VGLUT2 selectively in neurons defined by tyrosine hydroxylase promoter activity
K Nordenankar, CJA Smith-Anttila, N Schweizer, T Viereckel, C Birgner, et al.
Brain Structure and Function 220 (4), 2171–2190
- 2015Cited by 7
Targeted deletion of Vglut2 expression in the embryonal telencephalon promotes an anxiolytic phenotype of the adult mouse
K Nordenankar, A Bergfors, Å Wallén-Mackenzie
Upsala Journal of Medical Sciences 120 (3), 144–156
- 2014Cited by 176
The multilingual nature of dopamine neurons
LE Trudeau, TS Hnasko, Å Wallén-Mackenzie, M Morales, S Rayport, et al.
Progress in Brain Research 211, 141–164
- 2014Cited by 65
Limiting glutamate transmission in a Vglut2-expressing subpopulation of the subthalamic nucleus is sufficient to cause hyperlocomotion
N Schweizer, S Pupe, E Arvidsson, K Nordenankar, CJA Smith-Anttila, et al.
PNAS 111 (21), 7837–7842
- 2014Cited by 22
Age- and sex-dependence of dopamine release and capacity for recovery identified in the dorsal striatum of C57/Bl6J mice
E Arvidsson, T Viereckel, S Mikulovic, Å Wallén-Mackenzie
PLoS One 9 (6), e99592
- 2014Cited by 13
Haplotype-tag single nucleotide polymorphism analysis of the vesicular glutamate transporter (VGLUT) genes in severely alcoholic women
E Comasco, J Hallman, A Wallén-Mackenzie
Psychiatry Research 219 (2), 403–405
- 2012Cited by 89
Glutamate corelease promotes growth and survival of midbrain dopamine neurons
GM Fortin, MJ Bourque, JA Mendez, D Leo, K Nordenankar, C Birgner, et al.
Journal of Neuroscience 32 (48), 17477–17491
- 2012Cited by 52
Ultrastructural characterization of the mesostriatal dopamine innervation in mice, including two mouse lines of conditional VGLUT2 knockout in dopamine neurons
N Bérubé-Carrière, G Guay, GM Fortin, K Kullander, L Olson, et al.
European Journal of Neuroscience 35 (4), 527–538
- 2011Cited by 480
From glutamate co-release to vesicular synergy: vesicular glutamate transporters
S El Mestikawy, Å Wallén-Mackenzie, GM Fortin, L Descarries, et al.
Nature Reviews Neuroscience 12 (4), 204–216
- 2011Cited by 117
Enhanced sucrose and cocaine self-administration and cue-induced drug seeking after loss of VGLUT2 in midbrain dopamine neurons in mice
J Alsiö, K Nordenankar, E Arvidsson, C Birgner, S Mahmoudi, B Halbout, et al.
Journal of Neuroscience 31 (35), 12593–12603
- 2011Cited by 60
A sensory subpopulation depends on vesicular glutamate transporter 2 for mechanical pain, and together with substance P, inflammatory pain
MC Lagerström, K Rogoz, B Abrahamsen, AL Lind, C Ölund, C Smith, et al.
PNAS 108 (14), 5789–5794
- 2010Cited by 265
VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch
MC Lagerström, K Rogoz, B Abrahamsen, E Persson, B Reinius, et al.
Neuron 68 (3), 529–542
- 2010Cited by 149
VGLUT2 in dopamine neurons is required for psychostimulant-induced behavioral activation
C Birgner, K Nordenankar, M Lundblad, JA Mendez, C Smith, M le Grevès, et al.
PNAS 107 (1), 389–394
- 2010Cited by 79
Genetic inactivation of the vesicular glutamate transporter 2 (VGLUT2) in the mouse: what have we learnt about functional glutamatergic neurotransmission?
Å Wallén-Mackenzie, H Wootz, H Englund
Upsala Journal of Medical Sciences 115 (1), 11–20
- 2010Cited by 56
Reduced VGLUT2 expression increases motor neuron viability in Sod1G93A mice
H Wootz, A Enjin, Å Wallén-Mackenzie, D Lindholm, K Kullander
Neurobiology of Disease 37 (1), 58–66
- 2009Cited by 64
Restricted cortical and amygdaloid removal of vesicular glutamate transporter 2 in preadolescent mice impacts dopaminergic activity and neuronal circuitry of higher brain function
Å Wallén-Mackenzie, K Nordenankar, K Fejgin, MC Lagerström, et al.
Journal of Neuroscience 29 (7), 2238–2251
- 2006Cited by 239
Vesicular glutamate transporter 2 is required for central respiratory rhythm generation but not for locomotor central pattern generation
Å Wallén-Mackenzie, H Gezelius, M Thoby-Brisson, A Nygård, A Enjin, et al.
Journal of Neuroscience 26 (47), 12294–12307
- 2006Cited by 34
Role of glutamate in locomotor rhythm generating neuronal circuitry
H Gezelius, Å Wallén-Mackenzie, A Enjin, M Lagerström, K Kullander
Journal of Physiology-Paris 100 (5–6), 297–303
- 2004Cited by 200
Nurr1, an orphan nuclear receptor with essential functions in developing dopamine cells
T Perlmann, Å Wallén-Mackenzie
Cell and Tissue Research 318 (1), 45–52
- 2004Cited by 67
Congenital hypoventilation and impaired hypoxic response in Nurr1 mutant mice
E Nsegbe, Å Wallén-Mackenzie, S Dauger, JC Roux, Y Shvarev, et al.
The Journal of Physiology 556 (1), 43–59
- 2003Cited by 198
p57Kip2 cooperates with Nurr1 in developing dopamine cells
B Joseph, Å Wallén-Mackenzie, G Benoit, T Murata, E Joodmardi, S Okret, et al.
PNAS 100 (26), 15619–15624
- 2003Cited by 175
Nurr1-RXR heterodimers mediate RXR ligand-induced signaling in neuronal cells
Å Wallén-Mackenzie, A Mata de Urquiza, S Petersson, FJ Rodriguez, et al.
Genes & Development 17 (24), 3036–3047
- 2003Cited by 144
Transcriptional control of dopamine neuron development
Å Wallén, T Perlmann
Annals of the New York Academy of Sciences 991 (1), 48–60
- 2001Cited by 168
Orphan nuclear receptor Nurr1 is essential for Ret expression in midbrain dopamine neurons and in the brain stem
Å Wallén, DS Castro, RH Zetterström, M Karlén, L Olson, J Ericson, et al.
Molecular and Cellular Neuroscience 18 (6), 649–663
- 1999Cited by 587
Abnormal reaction to central nervous system injury in mice lacking glial fibrillary acidic protein and vimentin
M Pekny, CB Johansson, C Eliasson, J Stakeberg, Å Wallén, T Perlmann, et al.
The Journal of Cell Biology 145 (3), 503–514
- 1999Cited by 310
Fate of mesencephalic AHD2-expressing dopamine progenitor cells in NURR1 mutant mice
Å Wallén, RH Zetterström, L Solomin, M Arvidsson, L Olson, T Perlmann
Experimental Cell Research 253 (2), 737–746